Leukotriene B 4 receptors mediate the production of IL‐17, thus contributing to neutrophil‐dominant asthmatic airway inflammation
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چکیده
منابع مشابه
Airway responsiveness to leukotriene C4 (LTC4), leukotriene E4 (LTE4) and histamine in aspirin-sensitive asthmatic subjects.
We wanted to determine whether the airway response to inhaled leukotriene C4 (LTC4) is similar to inhaled leukotriene E4 (LTE4) in aspirin-sensitive asthma and, therefore, determined airway responsiveness to histamine, LTC4 and LTE4 in seven aspirin-sensitive subjects and 13 control asthmatic subjects, who were tolerant of aspirin. The concentration of inhaled lysine-aspirin which produced a 15...
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The prevalence and severity of bronchial asthma are higher in females than in males after puberty. Although antigen-specific CD8+ T cells play an important role in the development of asthma through their suppressive effect on cytokine production, the contribution of CD8+ T cells to sex differences in asthmatic responses remains unclear. In the present study, we investigated the sex-specific eff...
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The incidence of asthma worldwide has increased significantly over the past two decades, especially in young children and in inner cities. Although there are several contributing factors that promote severe asthmatic responses, uncontrolled inflammation leads to the most severe consequences. Chemokines are an interesting target for decreasing the inflammatory response and therefore altering the...
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IW. Emerson RJ, Graham WGB, Davis GS. Mineral dust and cell rocovery from the bronchoalveolar lavage of healthy Vermont granite workers. Am Rev Respir Dis, 1985, 132, 393-399. 8. Vallyathan V, Shi X, Dalal N, Irr W, Castranova V. Generation of free radicals from freshly fractured silica dust. Potential role in acute silica-induced lung injury. Am Rev Respir Dis, 1988, 138, 12131219. 9. Lugano E...
متن کاملAsthmatic Airway Inflammation is More Closely Related to Airway Hyperresponsiveness to Hypertonic Saline than to Methacholine
BACKGROUND Airway hyperresponsiveness (AHR) to direct stimuli, such as methacholine (MCh), is observed not only in asthma but other diseases. AHR to indirect stimuli is suggested to be more specific for asthma. The purpose of this study was to determine whether asthmatic airway inflammation is more closely related to AHR to hypertonic saline (HS), an indirect stimulus, than to MCh. METHODS Si...
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ژورنال
عنوان ژورنال: Allergy
سال: 2019
ISSN: 0105-4538,1398-9995
DOI: 10.1111/all.13789